Report: the best weight loss pills in the world

Report: the best weight loss pills in the world

Report: the best weight loss pills in the world


Do weight loss pills really work?

Yes. The majority of weight loss supplements issued as prescription medication are effective. They appear every now and again on the market, then they disappear again because their effectiveness is frequently dependent on dangerous substances contained therein.

In short: the more effective pills the higher chance that they contain dangerous substances.

Why? Because fast weight loss or appetite suppression is never a natural or suitable state for our bodies.

One of the most effective and popular ingredients in weight loss products is metformin – this is a drug used to treat type 2 diabetes. It has been used in medicine since 1957 and was discovered by a French doctor Jean Sterne.

Earlier medical Goat’s Rue (Galega officinalis) was used to treat diabetes, a plant used in folk medicine since the Middle Ages – used as a diuretic and substance causing sweating as well as a stimulant for lactation in women. Goat’s Rue was attributed magical properties and this is what the aforementioned metformin was precipitated from.

Since the beginning of 1950 when obesity was treated with amphetamine, weight loss products have come a long way. And even though every new generation of obesity medication is more dangerous than effective, experts continue to search for safe weight loss supplements, which work fast, effectively and don’t cause permanent, dangerous side effects.

Below we have presented the most popular weight loss supplements in the world, subjecting them to a detailed analysis:

Alli (contains orlistat)

Orlistat is an ingredient in medication called Xenical. Xenical is a prescription medication used in battling clinical obesity. Orlistat is available in smaller doses in Alli weight loss pills.

Alli should be taken three times per day during meals.

It causes weight loss by withholding digestion of 25% of fats contained in meals, thus creating a negative calorie balance. In practice this is around -100, up to -200 calories daily. Considering that we should eat around 2000-3000 (women - men) calories this is quite a good effort.

Alli is primarily used as an addition to a diet. Changing eating habits is the primary method for weight loss.

People attempting weight loss have noted an average 50% more effective weight loss process i.e. those on the same diet lose 10kg within a few to several weeks, whereas those additionally taking Alli lose 15kg within the same amount of time (research conducted by the GlaxoSmithKline Institute (GSK) Consumer Healthcare).

Many patients also decide to go on a low-fat diet in order to increase the effects of weight loss.


Faults: If you eat fatty food (over 30% of calories per meal, that is around 15 grams) then using Alli can result in diarrhoea, loose stools because the excess of fat is not absorbed by the body. The risk connected with this is dehydration.

Patients using Xenical often complain of similar side effects. In extreme cases eating fatty meals while taking Xenical, which has a high concentration of orlistat, leads to a lack of control over one’s internal organs. With Alli this problem is restricted to diarrhoea.

Using Alli increases the risk of losing vitamins because the lack of fat absorption by the body causes part of the vitamins to dissolve – for e.g. A and D only dissolve in fat.

Good choice?: Alli is intende for people who are overweight and have a body mass index (BMI) of at least 25. These weight loss pills are only recommended to people who eat frequently and don’t control the amount of fat in their meals. They also act as a deterrent because the consequence of fatty meals are stool problems.

Doctors and pharmacists are worried however, that Alli is too often taken by young women who use weight loss supplements as a product which guarantees weight loss without a diet and exercise i.e. they eat anything they want and take Alli like lollies all year round. Thereby they are exposing themselves to a loss of valuable vitamins and an unnecessary risk of dangerous side effects connected with long-term use.

For obese women subjected to the side effects of being overweight such as heart problems or diabetes, Alli is intended as a delicate product without a prescription and even then not for long-term use. In remaining cases it should not be used as a weight loss supplement replacing a diet and exercise.

Meridia (zawiera sibutramine)

The weight loss pills Meridia have a strong influence on the appetite centre in the brain, causing a feeling of satiety faster than the delivery of this message by insulin.

Meridia acts by changing the level of serotonin and noradrenaline – two substances in the human body supporting the regulation of satiety. It contains sibutramine, a derivative of amphetamine – a strongly stimulating psycho-active substance.

During clinical studies, obese patients who took medication containing sibutramine lost 5kg more than those who took a placebo (popular form of testing new medication; a certain group of patients receive full and valuable medication, the remainder are given a placebo).

Faults: Meridia rapidly increases blood pressure, increasing the risk of strokes or heart attacks. Distribution of the supplement has been temporarily banned in Italy and in 2002 the non-profit organization Public Citizen Group in USA submitted a petition to the FDA prohibiting distribution within the United States due to (as provided in the petition) 29 documented deaths and hundreds of undesired reactions in other patients.

These included: increased heart rate, high blood pressure, palpitations, arrhythmy.

FDA acknowledged the petitions but did not prohibit the distribution of Meridia.

The Abbott Company as the producer of these weight loss pills refers to clinical studies performed on a group of 12000 patients, which had positive results and approved the medication for sale.

The European Medicines Agency recommended the withdrawal of Meridia from sales within EU territory. Not everyone followed this recommendation. The medication is still sold, mainly through the Internet.

Good choice?: Meridia weight loss pills are used in treating clinical obesity with a BMI exceeding 27, additionally suffering from diabetes or a high cholesterol level.

This supplement is most frequently used in the case of people who have problems overcoming permanent hunger, despite being overweight and eating large meals. Sibutramine, an amphetamine derivative effectively suppresses hunger but is dangerous for the cardiovascular system. Therefore Meridia is only prescribed in extreme cases and for people over the age of 40. Usually this has to be someone with a low heart disease risk, below the age of 40.

One of the characteristics tests conducted by a doctor is frequent testing of the heart rhythm and monitoring its operation.

Glucophage (metformin) and Byetta (exenatide)

Both weight loss supplements are prescribed to patients suffering from diabetes. Sometimes, in clinical cases it is also used for obese patients who have a problem with insulin and don’t have confirmed diabetes.

Both Glucophage and Byetta are highly effective.

Glucophage is sold in the form of pills. It reduces the level of glucose and increases insulin sensitivity, thanks to which the feeling of hunger is reduced. 

Byetta is sold in the form of injections (shoulder, thigh). The enzyme delays the transport of food from the stomach to the small intestine, which in consequence extends the feeling of satiety.

New York Medical College performed a study on a large group of obese women of all ages. The metoformin in Glucophage caused a 10% weight reduction within a year for 80% of the studied women. The Byetta injection used once a week caused an average weight loss of 8kg within 15 weeks for patients experiencing problems with insulin.

Faults: In both cases similar side effects occur, frequently within the first several weeks of use – diarrhoea, nausea, upset stomach.

Good choice?: it’s hard  to mention choice because both medications are prescribed to people with certain conditions such as diabetes or problems with insulin.

These medications are definitely prescribed to people with a BMI exceeding 25.

Dietary supplements

Most people attempting to lose weight think that natural weight loss is a certain and safe method for weight loss., Unfortunately this isn’t always the case.

First of all, manufacturers frequently omit the truth when describing their product. The market for weight loss supplements around the world generates enormous profits – it has huge competition. The majority of dietary supplement manufacturers therefore inflate the value of their products, offering unreal effects within a short period of time (e.g. 15kg in 1 month without a diet or exercise).

Herbal weight loss pills are sold everywhere – from pharmacies, through department stores and affiliate Internet websites. The fact that they are solely made of herbs and natural ingredients does not mean that we can take them without limit or risk.

Dietary supplements do not reach the medicines control agency, such as the European Medicines Agency or the American FDA, which means that their content is basically a secret, because what is placed on the label is not always the same as what is actually included in the capsule.

Sanepid, toxicologists often check supplements introduced onto the market, but this is usually performed beyond the system or when adverse reactions are reported by the people taking them (therefore when the weight loss pills are already being sold).

Let’s take the bitter orange extract as an example, which is meant to replace ephedrine as an ingredient of many weight loss supplements (ephedrine was prohibited in 2004 after 16000 cases of adverse reactions, including several strokes and deaths). The extract causes an increased heart rate from 7 to 12%, which in the long run is not healthy because it can lead to a heart rhythm disorder and in consequence cardiac arrhythmia.

How to choose? Safe weight loss pills should contain ingredients which have approved effects and don’t cause side effects:

- green tea extract,

- linoleic acid (CLA)

- elements such as chrome (Cr)

- acai berries (they contain huge amounts of antioxidants)

- guarana extract (naturally stimulating and suppressing hunger)

- garcinia cambogia extract (contains HCA)

These types of substances function with various effects. It’s certain that much slower than the aforementioned prescription medicine, however they are definitely much safer and their effectiveness has been confirmed in laboratories back in the 70s.